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. 2015 Feb 25;8:509–518. doi: 10.2147/OTT.S76958

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© 2015 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Nimotuzumab inhibits phosphorylation of DNA repair-related proteins in KYSE-150R cells.

Notes: Nimotuzumab modulates the key molecules in DNA repair, including DNA-PKcs (A), ATM (A), and RAD51 (B). KYSE-150R cells were preincubated with nimotuzumab (1,000 nM) for 24 hours, followed by irradiation (6 Gy), as indicated. Total cell lysate was collected at the indicated time points after irradiation. GAPDH served as a loading control. The quantitative data for the Western blotting results are shown in “Supplementary material”.

Abbreviations: DNA, deoxyribonucleic acid; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.