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BRCA-deficient cells are highly reliant on BER as well as SSA and the error prone NHEJ pathway for DNA repair, both of which are influenced by PARPi.
Abbreviations: BER, base excision repair; DSB, double-strand DNA breaks; HR, homologous recombination; NHEJ, nonhomologous end joining; SSA, single-strand annealing; SSBs, single-strand DNA breaks; PARPi - poly (adenosine diphosphate [ADP]) ribose polymerase inhibitors.
