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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Feb 19;39(3):485–495. doi: 10.1111/acer.12630

Figure 1.

Figure 1

Timeline of operant sweetened ethanol self-administration in adolescent and adult rats. Adolescents arrived in the lab at postnatal day (P) 22, adults ∼P62. All rats were initially trained on a 10% sucrose solution (10S). Sweetened ethanol (10% sucrose + 10% ethanol, 10S10E) self-administration began at P36 for adolescents, ∼P76 for adults. Rats were tested on appetitive/consummatory, fixed ratio two (FR2), progressive ratio (PR), and cue-induced reinstatement (extinction responses after 13 days of abstinence) models of operant self-administration. A subset of rats had blood ethanol concentration (BEC) measured after operant self-administration. Control rats drank only 10S throughout the experiment.