Table 2. Spearman’s rank correlation coefficient and associated p-values between the expression of Notch receptors, ligands, target genes and the hypoxia markers.
Genes | HIF-1α | PGK1 | OPN | VEGF | CA9 | |
---|---|---|---|---|---|---|
Notch1 | Correlation Coefficient | .566(**) | .450(**) | .296(*) | .293(*) | 0.173 |
Sig. (1-tailed) | 0 | 0.003 | 0.042 | 0.044 | 0.161 | |
Notch2 | Correlation Coefficient | .434(**) | .420(**) | .322(*) | 0.222 | 0.19 |
Sig. (1-tailed) | 0.005 | 0.006 | 0.03 | 0.1 | 0.138 | |
Notch3 | Correlation Coefficient | .312(*) | 0.235 | 0.136 | 0.054 | -0.002 |
Sig. (1-tailed) | 0.034 | 0.087 | 0.218 | 0.379 | 0.495 | |
Notch4 | Correlation Coefficient | .494(**) | .373(*) | .378(*) | .400(**) | 0.121 |
Sig. (1-tailed) | 0.001 | 0.014 | 0.013 | 0.009 | 0.245 | |
Dll1 | Correlation Coefficient | .568(**) | .539(**) | .286(*) | 0.213 | 0.069 |
Sig. (1-tailed) | 0 | 0 | 0.048 | 0.109 | 0.348 | |
Dll3 | Correlation Coefficient | .551(**) | .499(**) | .332(*) | 0.249 | 0.034 |
Sig. (1-tailed) | 0 | 0.001 | 0.026 | 0.074 | 0.423 | |
Dll4 | Correlation Coefficient | .455(**) | .452(**) | 0.255 | .476(**) | 0.196 |
Sig. (1-tailed) | 0.003 | 0.003 | 0.07 | 0.002 | 0.13 | |
Jag1 | Correlation Coefficient | .402(**) | .293(*) | .288(*) | 0.23 | 0.232 |
Sig. (1-tailed) | 0.008 | 0.044 | 0.047 | 0.092 | 0.09 | |
Jag2 | Correlation Coefficient | .366(*) | .480(**) | .285(*) | .377(*) | -0.068 |
Sig. (1-tailed) | 0.015 | 0.002 | 0.049 | 0.013 | 0.348 | |
Hes1 | Correlation Coefficient | .599(**) | .668(**) | .572(**) | .471(**) | -0.147 |
Sig. (1-tailed) | 0 | 0 | 0 | 0.002 | 0.199 | |
Hes2 | Correlation Coefficient | 0.113 | 0.209 | 0.154 | .368(*) | .402(**) |
Sig. (1-tailed) | 0.258 | 0.114 | 0.188 | 0.015 | 0.008 | |
Hes5 | Correlation Coefficient | .506(**) | .361(*) | 0.2 | 0.114 | -0.032 |
Sig. (1-tailed) | 0.001 | 0.017 | 0.125 | 0.258 | 0.428 | |
Hes6 | Correlation Coefficient | .573(**) | .561(**) | .518(**) | .300(*) | 0.039 |
Sig. (1-tailed) | 0 | 0 | 0.001 | 0.04 | 0.412 | |
Hey1 | Correlation Coefficient | .790(**) | .790(**) | .459(**) | .499(**) | 0.088 |
Sig. (1-tailed) | 0 | 0 | 0.003 | 0.001 | 0.309 | |
Hey2 | Correlation Coefficient | .640(**) | .518(**) | 0.213 | 0.257 | -0.251 |
Sig. (1-tailed) | 0 | 0.001 | 0.109 | 0.068 | 0.073 |
(*) Correlations found significant at the 0.05 level
(**) Correlations found significant at the 0.01 level
Abbreviations: Sig, significance