Table 2. Spearman’s rank correlation coefficient and associated p-values between the expression of Notch receptors, ligands, target genes and the hypoxia markers.

Genes		HIF-1α	PGK1	OPN	VEGF	CA9
Notch1	Correlation Coefficient	.566(**)	.450(**)	.296(*)	.293(*)	0.173
	Sig. (1-tailed)	0	0.003	0.042	0.044	0.161
Notch2	Correlation Coefficient	.434(**)	.420(**)	.322(*)	0.222	0.19
	Sig. (1-tailed)	0.005	0.006	0.03	0.1	0.138
Notch3	Correlation Coefficient	.312(*)	0.235	0.136	0.054	-0.002
	Sig. (1-tailed)	0.034	0.087	0.218	0.379	0.495
Notch4	Correlation Coefficient	.494(**)	.373(*)	.378(*)	.400(**)	0.121
	Sig. (1-tailed)	0.001	0.014	0.013	0.009	0.245
Dll1	Correlation Coefficient	.568(**)	.539(**)	.286(*)	0.213	0.069
	Sig. (1-tailed)	0	0	0.048	0.109	0.348
Dll3	Correlation Coefficient	.551(**)	.499(**)	.332(*)	0.249	0.034
	Sig. (1-tailed)	0	0.001	0.026	0.074	0.423
Dll4	Correlation Coefficient	.455(**)	.452(**)	0.255	.476(**)	0.196
	Sig. (1-tailed)	0.003	0.003	0.07	0.002	0.13
Jag1	Correlation Coefficient	.402(**)	.293(*)	.288(*)	0.23	0.232
	Sig. (1-tailed)	0.008	0.044	0.047	0.092	0.09
Jag2	Correlation Coefficient	.366(*)	.480(**)	.285(*)	.377(*)	-0.068
	Sig. (1-tailed)	0.015	0.002	0.049	0.013	0.348
Hes1	Correlation Coefficient	.599(**)	.668(**)	.572(**)	.471(**)	-0.147
	Sig. (1-tailed)	0	0	0	0.002	0.199
Hes2	Correlation Coefficient	0.113	0.209	0.154	.368(*)	.402(**)
	Sig. (1-tailed)	0.258	0.114	0.188	0.015	0.008
Hes5	Correlation Coefficient	.506(**)	.361(*)	0.2	0.114	-0.032
	Sig. (1-tailed)	0.001	0.017	0.125	0.258	0.428
Hes6	Correlation Coefficient	.573(**)	.561(**)	.518(**)	.300(*)	0.039
	Sig. (1-tailed)	0	0	0.001	0.04	0.412
Hey1	Correlation Coefficient	.790(**)	.790(**)	.459(**)	.499(**)	0.088
	Sig. (1-tailed)	0	0	0.003	0.001	0.309
Hey2	Correlation Coefficient	.640(**)	.518(**)	0.213	0.257	-0.251
	Sig. (1-tailed)	0	0.001	0.109	0.068	0.073

(*) Correlations found significant at the 0.05 level

(**) Correlations found significant at the 0.01 level

Abbreviations: Sig, significance