Table 5. Summary of results of linear regression analysis using a combination of five hypoxia markers (HIF-1α, PGK1, VEGF, CA9 and OPN) as independent variables for their combined association with the expression level of individual Notch genes.
| Predictor: HIF-1α, PGK1, VEGF, CA9, OPN | |||||
|---|---|---|---|---|---|
| Notch signaling gene (Dependent variable) | r | r2 | p-value of regression model | β | |
| Dll1 | 0.58 | 0.34 | 0.029 | HIF-1α | 2.21 |
| PGK1 | 3.21 | ||||
| VEGF | -0.37 | ||||
| CA9 | -0.04 | ||||
| OPN | -0.73 | ||||
| Dll3 | 0.90 | 0.80 | 0.000 | HIF-1α | -0.46 |
| PGK1 | 0.12 | ||||
| VEGF | -0.07 | ||||
| CA9 | -0.004 | ||||
| OPN | 0.29 | ||||
| Hes1 | 0.57 | 0.32 | 0.037 | HIF-1α | 0.44 |
| PGK1 | 0.60 | ||||
| VEGF | -0.04 | ||||
| CA9 | -0.01 | ||||
| OPN | -0.09 | ||||
| Hes6 | 0.66 | 0.44 | 0.004 | HIF-1α | 0.27 |
| PGK1 | 0.38 | ||||
| VEGF | -0.005 | ||||
| CA9 | -0.008 | ||||
| OPN | -0.05 | ||||
| Hey1 | 0.58 | 0.34 | 0.030 | HIF-1α | 0.21 |
| PGK1 | 0.28 | ||||
| VEGF | -0.03 | ||||
| CA9 | -0.003 | ||||
| OPN | -0.05 | ||||
| Hey2 | 0.67 | 0.44 | 0.003 | HIF-1α | -0.09 |
| PGK1 | 0.08 | ||||
| VEGF | -0.02 | ||||
| CA9 | -0.001 | ||||
| OPN | 0.04 | ||||
Note: Only the Notch genes found to be significantly associated (p < 0.05) with the predictor of regression model have been shown.
Abbreviations: r, correlation coefficient; r2, coefficient of determination; β, regression coefficient