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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Clin Cancer Res. 2014 Dec 17;21(5):1063–1070. doi: 10.1158/1078-0432.CCR-14-1715

Figure 4. Longitudinal [18F]FFNP μPET/CT imaging of SSM2 tumor-bearing mice.

Figure 4

(A) Mice bearing SSM2 tumors were scanned 1 hr after [18F]FFNP injection. % ID/g of tumor and muscle were calculated. Ratio of % ID/g in tumor to % ID/g in muscle (i.e., tumor to muscle ratio [T:M]) from Sham (n = 6) and OVX mice before surgery (Day 0; n = 6) and on Days 3 and 4 post-surgery (n = 6) were graphed. ns = not significant. (B) 3D maximum intensity projection (MIP) from co-registered μPET and CT images of representative mice bearing SSM2 mammary tumors. Serial images from the same mouse in each group are shown. Arrows indicate tumors. (C) Representative PgR IHC images of SSM2 tumors on Day 4 following surgery. (D) Mean tumor diameter of SSM2 tumors before surgery (Day 0) and after surgery (Day 3). No significant difference in tumor size was observed between the two cohorts of mice. Representative results of two independent studies are shown.