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Response by baseline characteristics
| Baseline parameter | Responders/Evaluable | % |
|---|---|---|
| Total responders | 14/44 | 32 |
|
| ||
| Prior therapies | ||
| No HMA | 1/8 | 13 |
| HMA | 13/36 | 36 |
|
| ||
| Baseline cytopenias | ||
| 1 | 2/19 | 11 |
| 2–3 | 12/25 | 48 |
|
| ||
| Prior HMA and 2–3 cytopenias | 11/22 | 50 |
|
| ||
| IPSS risk | ||
| Low | 2/12 | 17 |
| Intermediate-1 | 12/32 | 38 |
|
| ||
| Phospho-p38 MAPK status at Baseline | ||
| Positive1 | 7/13 | 54 |
| Negative2 | 2/6 | 33 |
Positive defined as ≥ 5% p-p38[+] cells
One patient negative for phospho-p38 MAPK at baseline was not evaluable for HI
