Table 2.

IC₅₀ and selectivity ratio data obtained from six agriculturally relevant insect species AChE. Values for each inhibitor were tested for statistical differences across species, and those not labeled by the same lower case letter in that row represent significance at P < 0.05. Values for each species were tested for statistical differences across compounds, and those not labeled by the same upper case letter in that column represent significance at P < 0.05.

Inhibitor	PxAChE		OnAChE		DmAChE		MdAChE		DcAChE		Ap.mAChE
	a IC50	b SR	IC50	SR	IC50	SR	IC50	SR	IC50	SR	IC50	SR
Propoxur	3322 aA (2520–4120)	7.5	6710 bA (4770–8650)	15	104 dA (48–159)	0.2	152 dA (106–199)	0.3	942 cA (689–1194)	2	941 cA (853–1030)	2
Bendiocarb	217 aB (143–291)	1.3	336 aB (229–442)	2	27 cB (9–44)	0.2	58 bB (36–79)	0.3	92 bB (62–121)	0.5	49 bB (34–64)	0.3
1	675 aC (370–980)	6.5	2933 bC (2540–3330)	28	97 cA (66–129)	0.6	181 dA (142–220)	1.0	128 cB (100–156)	1.2	32 dB (17–47)	0.3
2	3411 aA (3160–3660)	15	7794 bA (7070–8520)	35	279 cC (215–343)	1.3	488 eC (434–541)	2.2	210 cC (147–273)	0.9	77 dB (29–125)	0.3
3	1681 aD (1400–2000)	3.5	10847 bD (8150–13500)	23	131 dA (78–183)	0.3	156 dA (129–182)	0.3	1067 aD (812–1345)	2.2	379 cC (307–451)	0.8
4	52166 aE (42800–62000)	492	20640 aE (14800–26400)	194	23 dB (8–38)	0.2	51 dB (14–87)	0.5	3193 bE (2830–3550)	30	1242 cA (883–1601)	11
5	> 100 uM aF	>232	81940 bF (71800–92000)	190	482 dD (334–630)	1.1	654 dC (493–815)	1.5	6189 cF (5790–6600)	14	5440 cD (3990–6890)	12

^aIC₅₀ values are shown as mean (n > 3) values and are expressed in nM (95% CI)

^bSR = selectivity index = IC₅₀ of agricultural insect AChE/IC₅₀ of An.gAChE (rounded to the nearest decimal point).