. Author manuscript; available in PMC: 2016 Mar 15.

Published in final edited form as: Bioorg Med Chem Lett. 2015 Jan 29;25(6):1292–1296. doi: 10.1016/j.bmcl.2015.01.048

Table 2.

Enzymatic Activity: Experimental K_i values were determined for the listed compounds and found to be very close to both the IC₅₀ and the calculated Ki values.

Compound	K_i¹(µM)	IC₅₀(µM)	K_i²(µM)
8	0.13	0.14	0.11
9	1.43	1.36	1.10
10	0.33	0.32	0.26

Experimental Ki

Calculated K_i using the Cheng-Prusoff Equation: $I C_{50} = K_{i} (1 + \frac{[S]}{K_{m}})$ where [S] = 200 µM and K_m = 830 µM.¹⁵