Table 3.
MIC values. MIC is the minimum inhibitory concentration while MBC is the minimum bactericidal concentration. MBCs were not determined for compounds with MICs ≥ 12.5 µg/mL. E. coli TolC- is the E. coli TolC efflux pump knockout mutant. MIC values reported here are the mean of at least two runs. MICs for 1 have been previously published14 but are included here for reference. NT = Not tested
| MIC / MBC (both in µg/mL) | |||||
|---|---|---|---|---|---|
| Compound | F. tularensis | S. aureus | MRSA | E. coli | E. coli TolC- |
| 1 | 7.8 | 25 | 50 | >200 | 6.25 |
| 2 | >12.5 | 12.5 | 12.5 | >12.5 | 6.3 / 12.5 |
| 3 | 3.9 / 9.4 | 5.5 / > 25.0 | 6.3 / 12.5 | >12.5 | 3.1 / 12.5 |
| 4 | 3.1 / 25.0 | 3.1 / 25.0 | 3.1 / 25.0 | >12.5 | 3.1 / >25.0 |
| 5 | >12.5 | 4.7 / >12.5 | 4.7 / >12.5 | >12.5 | >12.5 |
| 6 | >12.5 | >12.5 | >12.5 | >12.5 | >12.5 |
| 7 | 5.5 / 12.5 | > 12.5 | > 12.5 | >12.5 | 12.5 |
| 8 | 3.1 / 6.3 | 6.3 / 25.0 | 12.5 | >12.5 | 4.7 / 9.4 |
| 9 | >12.5 | >12.5 | >12.5 | >12.5 | >12.5 |
| 10 | 4.7 / 18.8 | 4.7 / >25.0 | 6.3 / >25.0 | >12.5 | 9.4 / 25.0 |