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. 2015 Mar 1;32(5):289–296. doi: 10.1089/neu.2014.3664

FIG. 4.

FIG. 4.

Number of bouts of sleep-wake states. The number of bouts for wake, non-rapid eye movement (NREM), and REM were assessed during the light and dark phases at post-injury day (PID) 6, 19, and 29. Significant increases in wake and NREM bouts were found during the dark (active) phase. (A) The amount of wake bouts changed based on PID (F(2,28)=5.679; p=0.009). (B) During the dark phase, there was an increase by the injured group in the number of wake bouts (F(2,28)=16.590; p=0.001). Injured animals showed an increase in wake bouts at PID 6 (**p<0.01 vs. sham) and 29 (*p<0.05 vs. sham). (C) No significance difference was found in NREM bouts during the light phase. (D) Injured animals showed an increased in the number of NREM bouts during the dark phase based on the experimental group (F(1,28)=8.961; p=0.010). Injured animals demonstrated an increase in the number of bouts at PID 6 (*p=0.010 vs. sham) and 29 (*p=0.041 vs. sham). (E) During the light phase, the number of REM bouts changed based on PID (F(2,28)=13.230; p<0.001). (F) In addition, during the dark phase, the number of REM bouts changed based on PID (F(2,28)=9.292; p<0.001). Analysis by one-way (groups) repeated measures (trials/time) analysis of variance (A-F) followed by Student-Newman-Keuls post hoc test. Mean±standard error of the mean; n=11/injured group, n=8 (sham). Sham is open circle with dashed line. Moderate injury is solid circle and solid line.