Figure 1.

Relationship between relative changes δ in average capillary transit time and capillary transit time heterogeneity (CTH) as quantified by the standard deviation of the capillary transit time distribution σ_c. Pairs of from studies performed in rat by Stefanovic et al¹⁷ and Schulte et al,¹⁸ and simulation results from a vascular anatomic network (VAN) model.²⁶ A decrease in σ_c with decreasing is observed both in the estimates based on experimental data and in the simulation data. Note that the individual data sets have been normalized with respect to baseline value, that is, the baseline of all data sets is in (0%, 0%). Numbers next to references in the caption refer to a coupling parameter θ_σ of a linear model relating and σ_c by . See Supplementary Material for details on the simulation and Jespersen and Østergaard²⁴ for details on estimates based on experimental data.