Figure 7.

Aged transforming growth factor-β1 (TGF) mice exhibited no significant deficit in the Morris water maze, and simvastatin (SV) had not effect on cognitive performance. TGF mice and SV-treated TGF mice did not significantly differ from wild-type (WT) controls in the time they needed to find the visible or hidden platform (left panel), despite the longer escape latency needed by SV-treated TGF mice on day 2 of the visible platform training. Similarly, TGF and SV-treated TGF mice were slightly but not significantly impaired in the probe trial (n=15 mice/group).