Fig. 4.

P2X4R KO mice showed a more severe HF phenotype after infarction. WT and KO mice were subjected to sham operation or LAD ligation and cardiac functions determined ninety days later. KO hearts had a lower + dP/dt (a), by ex vivo working heart preparation (n = 39) as well as a more reduced FS by in vivo echocardiography (b, n = 20) than WT hearts (n = 19 and 11 for ex and in vivo measurements respectively). Both WT and KO hearts showed lower + dP/dt and FS than either sham WT (n = 10 for + dP/dt, n = 6 for FS) or sham KO (n = 19 for + dP/dt, n = 9 for FS) hearts. *P < 0.05 for ligated WT vs. sham WT, sham KO or ligated KO. **P < 0.05 for ligated KO vs. sham WT or sham KO. P > 0.05 for sham WT vs. sham KO.

The figure and its legend are reproduced with permission from Wolters Kluwer Health (see Acknowledgment).