Table 1.
Classification of TB Status in MTB-Infected Rhesus Macaques
| Identification code | Infection/treatment | Classification | Age at infection (years) | Mamu subtype | TST (−2 weeks) | TST (3 weeks) | TST (7 weeks) | E or EN | Time to necropsy (days) |
|---|---|---|---|---|---|---|---|---|---|
| HD0001 | MTB | Active TB | 9.5 | NA | NNN | PPP | ND | E | 21 |
| HD0002 | MTB | Active TB | 10.3 | NA | NNN | PPP | ND | E | 25 |
| HD0003 | MTB | Active TB | 2.4 | A-11 and DR2011 | NNN | PPP | ND | E | 25 |
| HD0004 | MTB | Active TB | 3.5 | A-02, A-11, and B-01 | NNN | PPP | ND | E | 34 |
| HD0005 | MTB | Active TB | 6.6 | A-11 and B-17 | NNN | PPP | ND | E | 34 |
| HD0006 | MTB | Active TB | 3.7 | A-08 and B-01 | NNN | PPP | ND | E | 35 |
| HD0007 | MTB | Active TB | 7.8 | A-02 | NNN | PPP | ND | E | 38 |
| HD0008 | MTB | Active TB | 13.8 | A-02 and B-01 | NNN | PPP | ND | E | 51 |
| HD0009 | MTB | Active TB | 13.4 | A-02 and B-01 | NNN | PPP | ND | E | 52 |
| HD0010 | MTB | Active TB | 9.4 | A-02, A-08, B01, and DR2011 | NNN | PPP | ND | E | 61 |
| LD0001 | MTB | Active TB | 9.3 | A-02 and DR2011 | NNN | ND | PPP | E | 105 |
| LD0002 | MTB | Active TB | 6.5 | NA | NNN | ND | PPP | E | 133 |
| LD0003 | MTB | Active TB | 3.5 | NA | NNN | PPP | ND | E | 46 |
| LD0004 | MTB | Active TB | 3.7 | A08 | NNN | PPP | ND | E | 43 |
| LD0005 | MTB | LTBI | 9.4 | A-02 and B-17 | NNN | ND | PPP | EN | 126 |
| LD0006 | MTB | LTBI | 9.4 | A-08 | NNN | ND | PPP | EN | 136 |
| LD0007 | MTB | LTBI | 11.6 | NA | NNN | ND | PPP | EN | 53 |
| LD0008 | MTB | LTBI | 12.5 | A-01 and DR2011 | NNN | ND | PPP | EN | 52 |
| LD0009 | MTB | LTBI | 4.5 | DR2011 | NNN | ND | PPP | EN | 127 |
| LD0010 | MTB | LTBI | 3.4 | A-01 and A-08 | NNN | ND | PPP | EN | 120 |
| LD0011 | MTB | LTBI | 6.4 | NA | NNN | PPP | PPP | EN | 190 |
| LD0012 | MTB or SIV | Reactivation | 3.1 | A08 | NNN | ND | PPP | E | 147 |
| LD0013 | MTB or SIV | Reactivation | 3.5 | A-01, A-02, and DR2011 | NNN | ND | PPP | E | 114 |
| LD0014 | MTB or SIV | Reactivation | 3.5 | B-01 | NNN | ND | PPP | E | 112 |
| LD0015 | MTB or SIV | Reactivation | 3.3 | A-01 and B-01 | NNN | ND | PPP | E | 127 |
| LD0016 | MTB or SIV | Reactivation | 3.4 | A-01 and B-01 | NNN | ND | PPP | E | 167 |
| LD0017 | MTB or SIV | Reactivation | 8.5 | A-11 | NNN | ND | PPP | E | 153 |
| LD0018 | MTB or SIV | Reactivation | 3.4 | A-02 and B-01 | NNN | ND | PPP | E | 104 |
| LD0019 | MTB or SIV | Reactivation | 2.2 | NA | NNN | ND | PPP | E | 167 |
| LD0020 | MTB or SIV | LTBI | 4.5 | A-01 and B-17 | NNN | ND | PPP | EN | 154 |
| LD0021 | MTB or SIV | LTBI | 8.2 | A-11 | NNN | ND | PPP | EN | 126 |
| LD0022 | MTB or SIV | LTBI | 3.1 | A-01 and A-08 | NNN | ND | PPP | EN | 137 |
Animals were divided into two subsets on the basis of high- and low-dose MTB infection. TST data were obtained 24, 48, and 72 hours after mammalian tuberculin injection. Negative results for the TST were represented with an N, and a P showed positive results. SIV coinfection was performed 63 days after MTB infection.
E, euthanasia; EN, experimental necropsy; HD, animals that received high-dose MTB infection when included in animal identification code; LD, animals that received low-dose MTB infection when included in identification code; LTBI, latent tuberculosis infection; MTB, Mycobacterium tuberculosis; N, a single negative; NA, data not available; ND, not done; P, a single positive test result at each time of reading; SIV, simian immunodeficiency virus; TB, tuberculosis; TST, tuberculin skin test.