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. 2015 Mar;185(3):808–819. doi: 10.1016/j.ajpath.2014.11.019

Figure 6.

Figure 6

Serum cytokine concentrations are greater in ob/ob mice and unaffected by lipase inhibition early in the disease. Box plots depicting serum IL-6 (A), monocyte chemoattractant protein 1 (MCP-1) (B), resistin (C), and tumor necrosis factor (TNF)-α (D) being significantly higher in ob/ob mice versus lean mice. These concentrations are unaffected with orlistat treatment on day 2 and are reduced by day 5. ∗P < 0.05 versus controls in the respective lean and ob/ob mice; †P < 0.05 versus ob/ob cerulein (CR); ‡P < 0.05 for the lean CR for 1 day versus ob/ob CR. Box plots show the means (dashed lines), medians (solid lines), 25th and 75th percentiles (boxes), and 10th and 90th percentiles (brackets). n ≥ 8 in each group. CR1, lean mice sacrificed at the end of day 1; CR2, lean mice sacrificed at the end of day 2; CRO2, mice given orlistat and sacrificed at the end of 2 days; CRO5, mice given orlistat and sacrificed at the end of 5 days; Veh, vehicle.