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. 2015 Mar 3;10(3):e0118473. doi: 10.1371/journal.pone.0118473

Fig 9. S1P stimulates c-Src/EGFR, PDGFR/p38 MAPK, p42/p44 MAPK/Akt- or JNK1/2-dependent AP-1 activation are mediated via S1PR1/3.

Fig 9

(A) Cells were transfected with siRNA of scrambled, S1PR1, or S1PR3, and then incubated with S1P (10 μM) for the indicated time intervals. The levels of phospho-c-Src, phospho-EGFR, phospho-PDGFR, phospho-p38 MAPK, phospho-p42/p44 MAPK, phospho-JNK1/2, phospho-c-Jun, and GAPDH proteins were determined by Western blot. The figure represents one of three individual experiments (n = 3).