Table 2. Features of CLL patients with clinical Binet Stage B/C.
| Patient Number | IGHV Mutational Status | ZAP70 | CD38 | FISH | Karyotype | |||
|---|---|---|---|---|---|---|---|---|
| Del 17p | Del 11q | Del 13q | Trisomy 12 | |||||
| 47 | UM | + | + | − | +[174/200] | +mono[193/200] | − | Normal |
| 48 | M | − | − | − | − | − | − | Normal |
| 49 | M | − | − | − | +[111/200] | +mono[170/200] | − | nd |
| 50 | M | − | − | − | − | +mono[93/200] | − | Failure |
| 51 | UM | + | − | − | − | − | − | Failure |
| 52 | UM | Grey zone | + | − | +[176/200] | +mono[43/200] | − | 1 abnormality |
| 53 | UM | − | − | +[178/200] | − | +mono[20/200] | − | Complex |
| 54 | UM | + | − | − | +[45/200] | +mono[83/200] | − | Complex |
| 55 | M | − | + | − | − | +bi[166/200] | − | Normal |
| 56 | M | − | + | − | − | − | − | 1 abnormality |
| 57 | UM | + | − | − | − | +mono[200/200] | − | 1 abnormality |
| 58 | M | − | − | − | − | +mono[165/200] | − | 1 abnormality |
| 59 | M | − | − | +[34/200] | − | +mono[15/200]/bi[171/200] | − | Failure |
| 60 | UM | + | − | − | − | +mono[180/200] | − | Normal |
| 61 | UM | + | + | − | +[149/200] | +mono[146/200] | − | Complex |
| 62 | M | − | − | +[195/200] | − | +mono[193/200] | − | Complex |
| 63 | UM | + | + | − | +[181/200] | − | − | 1 abnormality |
| 64 | UM | + | − | − | − | − | − | Normal |
| 65 | M | − | Nd | − | − | +bi[123/200] | +[123/200] | 2 abnormalities |
| 66 | M | nd | + | − | − | − | − | 1 abnormality |
| 67 | UM | + | − | +[181/200] | − | − | − | 2 abnormalities |
| 68 | M | − | − | − | − | +mono[174/200] | − | Normal |
| 69 | UM | + | + | − | +[59/200] | +mono[10/200]/bi[55/200] | − | Complex |
| 70 | M | − | − | − | − | − | +[125/200] | 1 abnormality |
| 71 | UM | − | − | +[193/200] | − | − | − | Complex |
| 72 | UM | + | + | +[186/200] | − | − | − | Complex |
| 73 | M | − | − | +[195/200] | − | +bi[192/200] | − | Complex |
| 74 | UM | + | − | +[33/200] | − | − | +[110/200] | Failure |
| 75 | M | + | − | − | − | +mono[183/200] | − | nd |
| 76 | UM | + | − | − | − | +mono[140/200] | − | Complex |
| 77 | UM | − | − | − | +[121/200] | +mono[122/200] | − | Normal |
| 78 | UM | + | + | − | +[169/200] | +mono[173/200] | − | 2 abnormalities |
| 79 | UM | + | − | − | − | − | +[146/200] | nd |
| 80 | UM | + | + | − | − | +mono[43/200] | − | Complex |
IGHV mutational status homology ≥ 98%: M, mutated; UM, unmutated. ZAP70 is considered negative when the ratio (R) of mean fluorescence of T lymphocytes/mean fluorescence of CLL B lymphocytes ≥ 12. ZAP70 is considered positive if R ≤ 10, and “grey zone” if 10 < R < 12. CD38 is considered positive when the percentage of positive leukemic cells is ≥30%. FISH: score of interphasic cells with an abnormality. Complex karyotype is ≥3 chromosomal abnormalities. bi, biallelic; Del, deletion; mono, monoallelic; nd, not done.