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. 2015 Mar 3;10(3):e0117937. doi: 10.1371/journal.pone.0117937

Fig 6. Proposed model for compression-induced dephosphorylation of myosin regulatory light chain (MRLC).

Fig 6

In C2C12 cells subjected to compressive loading, RhoA and adenylyl cyclase activation were induced. Adenylyl cyclase activation may activate protein kinase A (PKA) via cAMP production. RhoA phosphorylation by PKA induces decreasing affinity of RhoA for ROCK and inactivates ROCK [19]. Myosin phosphatase target subunit 1 (MYPT1) at Thr852 which is kinase substrate of ROCK is dephosphorylated. Accordingly, myosin phosphatase (MLCP) is activated and dephosphorylates MRLC.