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. 2015 Jan 29;8(3):295–309. doi: 10.1242/dmm.018754

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Apolipoprotein gene ancestry analysis. (A) There is low sequence similarity between zebrafish and human apolipoprotein orthologs. Zebrafish genes are listed next to the top BLASTp hit against the human RefSeq protein database. The percentage similarity between zebrafish and human orthologs was determined by Needleman–Wunsch amino acid pairwise sequence alignment. (B) Phylogentetic tree of human, zebrafish, mouse, chicken and coelacanth APOA-I, APOB, APOE and APOA-IV assembled from amino acid sequences as described in the Materials and Methods. Bootstrap support for each clade is reported in light blue (≥70 interpreted as significant). (C) Most zebrafish apolipoprotein genes share syntenic gene regions with their human orthologs. Schematic representation of human and zebrafish chromosomes regions with lines connecting human and zebrafish orthologs.