Table 2.
Resistance mutations in the UL54 gene confirmed by Marker Transfer. Resistance ratios are marked in bold numbers.
| Mutation | GCV ratio | PFA ratio | CDV ratio | References |
|---|---|---|---|---|
| D301N | 2.6 | 0.5 | 3 | [70] |
| N408D | 4.9 | 1.3 | 5.6 | [35] |
| N408K | 4.2 | 0.7 | 21 | [71] |
| N410K | 2.9 | 0.8 | 3 | [70] |
| F412C | 4.2 | 1.2 | 18 | [72] |
| F412V | 4.3 | 1.1 | 15.5 | [35] |
| D413A | 6.5 | 0.8 | 11 | [56] |
| D413E | 4.8 | 0.8 | 4.3 | [70,87] |
| N495K | 1.1 | 3.4 | 1.1 | [73] |
| L501I | 6 | 1.4 | 9.1 | [35] |
| T503I | 2.9 | 0.5 | 6.1 | [70] |
| K513E | 5 | 1.4 | 9.1 | [35] |
| K513N | 6 | 1.1 | 12.5 | [74] |
| D515E | 2.4 | 1.1 | 1.6 | [69] |
| L516R | 2.1 | 0.8 | 5.1 | [70] |
| I521T | 3.1 | 0.9 | 3.9 | [75] |
| P522A | 3 | 1 | 4.1 | [75] |
| P522S | 3.1 | 1.1 | 3.6 | [35] |
| L545S | 3.5 | 1.2 | 9.1 | [35] |
| D588E | 1.3 | 2.3 | 1.1 | [35,77] |
| D588N | 3.8 | 3.2–9 | 2.7 | [76] |
| T700A | 0.9 | 4.7 | 1.5 | [78] |
| V715M | 1 | 5.5 | 1.1 | [78] |
| E756D | 1.2 | 3.4 | 0.7 | [70] |
| E756K | 3.5 | > 8 | 2.2 | [70,87] |
| E756Q | 1.7 | 4.3 | 1 | [79] |
| L776M | 2.5 | 3.5 | 1 | [80] |
| V781I | 1–4 | 4–5.2 | 1.2 | [35,76] |
| V787L | 2.4 | 4.1 | 1 | [79] |
| L802M | 1.1–3.5 | 3.2–10.8 | 0.9–1.8 | [35,72] |
| K805Q | 1 | 0.18 | 2.2 | [35] |
| A809V | 2.6 | 6.3 | 1.7 | [81] |
| V812L | 2.5 | 2.9 | 3.2 | [74] |
| T813S | 2.5 | 4.9 | 2.7 | [82] |
| T821I | 4.5 | 21 | 1.9 | [35] |
| A834P | 5.4 | 6.4 | 3 | [71] |
| T838A | 1.8 | 2.4 | 0.8 | [77] |
| G841A | 3.2 | 4.3 | 2.6 | [82] |
| Del918–982 | 8.3 | 3.6 | 2.8 | [83] |
| A987G | 5.3 | 1.2 | 11.3 | [84] |
| D301N | 2.6 | 0.5 | 3 | [74] |
| N408D | 4.9 | 1.3 | 5.6 | [41] |
| N408K | 4.2 | 0.7 | 21 | [75] |
| N408S | 3.1 | Nd | 7.5 | [92] |
| N410K | 2.9 | 0.8 | 3 | [74] |
| F412C | 4.2 | 1.2 | 18 | [76] |
| F412V | 4.3 | 1.1 | 15.5 | [41] |
| F412L | 4.6 | 1.1 × | 9.4× | [93] |
| F412S | 5.3 | 0.8 × | 13× | [93] |
| D413A | 6.5 | 0.8 | 11 | [77] |
| D413E | 4.8 | 0.8 | 4.3 | [74,91] |
| P488R | 3.5 | Nd | 7.9 | [93] |
| N495K | 1.1 | 3.4 | 1.1 | [77] |
| L501I | 6 | 1.4 | 9.1 | [41] |
| T503I | 2.9 | 0.5 | 6.1 | [74] |
| K513E | 5 | 1.4 | 9.1 | [41] |
| K513N | 6 | 1.1 | 12.5 | [78] |
| D515E | 2.4 | 1.1 | 1.6 | [73] |
| L516R | 2.1 | 0.8 | 5.1 | [74] |
| I521T | 3.1 | 0.9 | 3.9 | [79] |
| P522A | 3 | 1 | 4.1 | [79] |
| P522S | 3.1 | 1.1 | 3.6 | [41] |
| C539R | 3.2 | Nd | 13.3 | [93] |
| L545S | 3.5 | 1.2 | 9.1 | [41] |
| L545W | 5.9 | 1.3 × | 6.3× | [93] |
| Q578H | 3.3 | 4.5 | 2.3 | [93] |
| Q578L | 1.9 | 3.0 | 0.8 | [93] |
| D588E | 1.3 | 2.3 | 1.1 | [41,81] |
| D588N | 3.8 | 3.2–9 | 2.7 | [80] |
| T700A | 0.9 | 4.7 | 1.5 | [82] |
| V715M | 1 | 5.5 | 1.1 | [82] |
| E756D | 1.2 | 3.4 | 0.7 | [74] |
| E756K | 3.5 | > 8 | 2.2 | [74,91] |
| E756Q | 1.7 | 4.3 | 1 | [83] |
| L776M | 2.5 | 3.5 | 1 | [84] |
| V781I | 1–4 | 4–5.2 | 1.2 | [41,80] |
| V787L | 2.4 | 4.1 | 1 | [83] |
| L802M | 1.1–3.5 | 3.2–10.8 | 0.9–1.8 | [41,76] |
| K805Q | 1 | 0.18 | 2.2 | [41] |
| A809V | 2.6 | 6.3 | 1.7 | [85] |
| V812L | 2.5 | 2.9 | 3.2 | [78] |
| T813S | 2.5 | 4.9 | 2.7 | [86] |
| T821I | 4.5 | 21 | 1.9 | [41] |
| A834P | 5.4 | 6.4 | 3 | [75] |
| T838A | 1.8 | 2.4 | 0.8 | [81] |
| G841A | 3.2 | 4.3 | 2.6 | [86] |
| Del981–982 | 8.3 | 3.6 | 2.8 | [87] |
| A987G | 5.3 | 1.2 | 11.3 | [88] |