Table 1.
Association studies confirming the role of NLRP3 and CARD8 gene polymorphisms in inflammatory disease.
| Disease | Gene | SNPs | Cohorts | Reference |
|---|---|---|---|---|
| CD | NLRP3 | rs4353135, rs4266924, rs6672995, rs10733113, rs107635144, rs55646866 | European | [47] |
| CARD8 | rs2043211 | Korean, British | [48, 49] | |
| rs1972619 | Korean | [48] | ||
| NLRP3/CARD8 | rs35829419/rs2043211 | New Zealander, Swedish | [50, 51] | |
|
| ||||
| CVD | NLRP3 | rs35829419 | Swedish (MI) | [52] |
| CARD8 | rs2043211 | Chinese (ischemic stroke) | [53] | |
| NLRP3/CARD8 | rs35829419/rs2043211 | New Zealander (AAA) | [54] | |
|
| ||||
| RA | NLRP3 | rs4353135 | Taiwanese | [55] |
| CARD8 | rs2043211 | Swedish | [56] | |
| NLRP3/CARD8 | rs35829419/rs2043211 | Swedish | [57] | |
|
| ||||
| AS | CARD8 | rs2043211 | Swedish | [57] |
|
| ||||
| Celiac disease | NLRP3 | rs35829419 | Italian and Brazilian | [58, 59] |
|
| ||||
| T1D | NLRP3 | rs10754558 | Brazilian | [58] |
|
| ||||
| Gout | NLRP3 | rs7512998 | Chinese | [60] |
|
| ||||
| AD | NLRP3 | rs35829419 | Northern Chinese | [61] |
| rs10754558 | Northern Chinese | [61] | ||
| rs2027432 | Northern Chinese | [61] | ||
| CARD8 | rs2043211 | Brazilian | [62] | |
CD: Crohn's disease; CVD: Cardiovascular diseases; RA: Rheumatoid arthritis; AS: Ankylosing spondylitis; T1D: Type 1 diabetes; AD: Alzheimer's disease; MI: Myocardial infarction; AAA: Abdominal aortic aneurysms.