Table 2.
Gene variants distribution and associated ORs values. The ORs have been calculated comparing the number of the polymorphic homozygotes with the rest of genotypes among cases versus the controls.
| Gene variant | FPN1 (SLC40A1) | Tf | HFE | HFE | HEPC (HAMP) | |||||||||
| −8CG | C1, C2 | H63D | C282Y | −582AG | ||||||||||
|
| ||||||||||||||
| Cases | 200 | 200 | 200 | 200 | 200 | |||||||||
| Controls | 400 | 400 | 400 | 400 | 400 | |||||||||
|
| ||||||||||||||
| Genotypes | CC | CG | GG | C1C1 | C1C2 | C2C2 | HH | HD | DD | CC | CY | AA | AG | GG |
|
| ||||||||||||||
| Cases | 123 | 62 | 15 | 139 | 53 | 8 | 142 | 56 | 2 | 193 | 7 | 111 | 77 | 12 |
| % | 61.5 | 31 | 7.5 | 69.5 | 26.5 | 4 | 71 | 28 | 1 | 96.5 | 3.5 | 55.5 | 38.5 | 6 |
| Controls | 268 | 125 | 7 | 270 | 119 | 11 | 294 | 98 | 8 | 383 | 17 | 229 | 147 | 24 |
| % | 67 | 31.25 | 1.75 | 67.5 | 29.75 | 2.75 | 73.5 | 24.5 | 2 | 95.75 | 4.25 | 57.25 | 36.75 | 6 |
| P value | 0.001 | 0.63 | 0.55 | 0.80 | 0.92 | |||||||||
| OR (95% CI) | 4.27 (2.65–6.89) | 1.39 (0.71–2.73) | 0.52 (0.13–2.08) | 0.82 (0.33–2.0) | 1.03 (0.60–1.76) | |||||||||
|
| ||||||||||||||
| Alleles | C | G | C1 | C2 | H | D | C | Y | A | G | ||||
|
| ||||||||||||||
| Cases number/% | 308/77 | 92/23 | 331/82.75 | 69/17.25 | 340/85 | 60/15 | 393/98.25 | 7/1.75 | 299/74.75 | 101/25.25 | ||||
| Controls number/% | 661/82.6 | 139/17.4 | 659/82.4 | 141/17.6 | 686/85.7 | 114/14.3 | 783/97.9 | 17/2.1 | 605/75.6 | 195/24.4 | ||||
| P value | 0.02 | 0.94 | 0.79 | 0.83 | 0.79 | |||||||||
| OR (95% CI) | 1.42 (1.06–1.91) | 0.97 (0.71–1.34) | 1.06 (0.76–1.49) | 0.82 (0.34–1.99) | 1.05 (0.8–1.38) | |||||||||