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. 2015 Mar 4;5:8755. doi: 10.1038/srep08755

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(a). Schematic diagram of the mouse Cryba1 gene showing the transcription start site (TSS) and the two STAT3 binding sites, one 2750 bp upstream of the start site (promoter region) and the other 1942 bp from the TSS in Intron 2. Exons are shown in boxes. (b). Treatment of WT astrocytes with IL-6 resulted in 4.5 fold increase in the expression of Cryba1 and Stattic treatment decreased the expression of Cryba1 by ~51% compared to vehicle treated astrocytes. In astrocytes treated with both IL-6 and Stattic the expression of Cryba1 was reduced by ~73% compared to astrocytes treated with IL-6 alone. Error bar indicate s.d.; *P<0.05.