Table 1. GO enrichment of CHMGs and CLMGs.

Gene group	GO terms	Number of genes in the gene group/all genes in the GO group	P-value for enrichment
Conserved highly methylated genes	regulation of apoptosis	5/14	0.0078
	catecholamine metabolic process	2/2	0.013
	lipid metabolic process	7/30	0.019
Conserved lowly methylated genes	regulation of transcription, DNA-dependent	182/248	4.59E-05
	G-protein coupled receptor protein signaling pathway	64/142	0.00017
	ubiquitin-dependent protein catabolic process	30/36	0.0067
	protein folding	29/35	0.0093
	vesicle-mediated transport	29/36	0.020
	protein amino acid phosphorylation	135/197	0.032
	post-translational protein modification	17/20	0.039