Table 1.
Studies reporting associations of cardiac troponin T and high-sensitivity cardiac troponin T with outcomes in CKD
| Study (Reference) | Patients (n) | Study Design | Sample | Outcomes |
|---|---|---|---|---|
| Dubin et al. (2) | 2464 CRIC | Cross-sectional | Asymptomatic outpatients, eGFR 20–70 ml/min per 1.73 m2 | hs-cTnT independently associated with lower eGFR; aOR, 2.83 (95% CI, 2.41 to 3.33) for eGFR<30 ml/min per 1.73 m2 versus >60 ml/min per 1.73 m2, higher LVMI, and lower LVEF |
| Mishra et al. (21) | 3243 CRIC | Cross-sectional | Asymptomatic outpatients with eGFR<60 ml/min per 1.73 m2 and CAD | hs-cTnT>24 pg/ml versus undetectable independently associated with LVH (aOR, 2.43 [95% CI, 1.44 to 4.09]) and LVSD (aOR, 1.4 [95% CI, 1.2 to 1.7]), but not LVDD |
| deFilippi et al. (17) | 148 (50% diabetic) | Cross-sectional | Outpatients from United States with known CAD and eGFR<60 ml/min per 1.73 m2 | hs-cTnT independently associated with LVMI, decreased GFR, and increased UACR |
| Kitagawa et al. (19) | 93 (nondiabetic) | Cross-sectional | Japanese inpatients with nondiabetic CKD stages 1–5 | hs-cTnT≥9 pg/ml and BNP≥20 pg/ml were best cutoffs for severe LVDD |
| Abbas et al. (13) | 222 | Longitudinal | Asymptomatic British outpatients with CKD stages 3–5 | Detectable versus undetectable cTnT conferred increased risk for all-cause mortality (uOR, 3.47 [95% CI, 1.27 to 10.39]) (n=23) |
| Goicoechea et al. (14) | 176 | Longitudinal | Asymptomatic Spanish outpatients; n=128 with creatinine clearance <60 ml/min | Detectable versus undetectable cTnT increased hazard of CV event (uHR, 12.3 [95% CI, 4.91 to 31.02]) (n=21) |
| Chrysochou et al. (16) | 82 | Longitudinal | Asymptomatic British outpatients with ARVD at single center | cTnT independently associated with all-cause mortality (uHR, 3.9 [95% CI, 1.8 to 8.5]) |
| Scheven et al. (15) | 8121 PREVEND | Longitudinal | Asymptomatic Dutch outpatients; 18% with CKD (UACR>30 mg/g or eGFR<60 ml/min per 1.73 m2) | hs-cTnT independently associated with CV events (adjusted for eGFR, albuminuria, and CV risk factors) (aHR, 1.18 [95% CI not given; P=0.03]) |
| Hasegawa et al. (18) | 442 | Longitudinal | Asymptomatic Japanese outpatients with eGFR<60 ml/min per 1.73 m2 | hs-cTnT≥33 versus ≤9 pg/ml conferred increased risk for CV events (aHR, 6.18 [95% CI, 1.38 to 27.7]) (n=63) |
CRIC, Chronic Renal Insufficiency Cohort; PREVEND, Prevention of Renal and Vascular End Stage Diseases; CAD, coronary artery disease; ARVD, atheromatous renovascular disease; UACR, urinary albumin-to-creatinine ratio; hs-cTnT, highly sensitive cardiac troponin T; aOR, adjusted odds ratio; 95% CI, 95% confidence interval; LVMI, left ventricular mass index; LVEF, left ventricular ejection fraction; LVH, left ventricular hypertrophy; LVSD, left ventricular systolic dysfunction; LVDD, left ventricular diastolic dysfunction; BNP, brain natriuretic peptide; uOR, unadjusted odds ratio; CV, cardiovascular; uHR, unadjusted hazard ratio; aHR, adjusted hazard ratio.