Table 3.
Multivariate regression of carotid IMT on genotypes and covariates by race
| White | Black | Total | ||||
|---|---|---|---|---|---|---|
| β | P | β | P | β | P | |
| Black race | — | — | — | — | 0.20 | 0.128 |
| Female sex | −0.052 | <0.0001 | −0.03 | 0.151 | −0.05 | <0.0001 |
| Age | 0.007 | <0.0001 | 0.008 | 0.0003 | 0.007 | <0.0001 |
| BMI | 0.0001 | 0.924 | −0.002 | 0.200 | −0.0009 | 0.324 |
| MAP | 0.002 | 0.002 | 0.003 | <0.0001 | 0.003 | <0.0001 |
| TG /HDLC | 0.02 | 0.087 | 0.015 | 0.366 | 0.01 | 0.069 |
| HOMA-IR | 0.02 | 0.140 | −0.003 | 0.857 | 0.01 | 0.099 |
| Smoking | 0.03 | 0.002 | −0.008 | 0.693 | 0.03 | 0.007 |
| GNB3 C825T | 0.0006 | 0.975 | −0.016 | 0.385 | −0.009 | 0.489 |
| eNOS G894T | −0.02 | 0.142 | −0.016 | 0.478 | −0.016 | 0.109 |
Smoking: 1 = smoker, 0 = nonsmoker.
GNB3 C825T: 1 = C825/C825 and C825/T825, 0 = T825/T825.
eNOS G894T: 1 = T894/T894 and G894/T894, 0 = G894/G894.
BMI, body mass index; eNOS, endothelial nitric oxide synthase; GNB3, G-protein β3 subunit; HDLC, high-density lipoprotein cholesterol ratio; HOMA-IR, homeostasis model assessment of insulin resistance; IMT, intima-media thickness; MAP, mean arterial pressure; TG, triglycerides.