Table 6.
Interaction between childhood trauma and CREB1 genetic polymorphisms
| Variable | Case | Control | OR (95% CI) | ORa (95% CI) |
|---|---|---|---|---|
| rs11904814 | ||||
| TT and no trauma | 79 | 84 | 1 | 1 |
| TG or GG and no trauma | 449 | 470 | 1.02 (0.72-1.42) | 1.05 (0.75-1.48) |
| TT and trauma | 4 | 2 | 2.13 (0.38-11.94) | 2.37 (0.41-13.61) |
| TG or GG and trauma | 54 | 30 | 1.91 (1.11-3.29) | 1.43 (0.80-2.54) |
| rs6740584 | ||||
| TT and no trauma | 194 | 210 | 1 | 1 |
| TC or CC and no trauma | 334 | 344 | 0.69 (0.82-1.35) | 1.05 (0.82-1.35) |
| TT and trauma | 12 | 10 | 1.30 (0.55-3.08) | 0.76 (0.34-1.70) |
| TC or CC and trauma | 46 | 22 | 2.26 (1.31-3.90) | 2.19 (1.16-4.15) |
| rs2253206 | ||||
| GG and no trauma | 82 | 83 | 1 | 1 |
| GA or AA and no trauma | 446 | 471 | 0.96 (0.69-1.34) | 1.02 (0.73-1.42) |
| GG and trauma | 4 | 6 | 0.68 (0.18-2.48) | 2.19 (0.39-12.50) |
| GA or AA and trauma | 54 | 26 | 2.10 (1.20-3.68) | 1.37 (0.78-2.41) |
| rs2551941 | ||||
| AA and no trauma | 99 | 105 | 1 | 1 |
| AT or TT and no trauma | 429 | 449 | 1.01 (0.75-1.37) | 1.04 (0.76-1.41) |
| AA and trauma | 6 | 6 | 1.06 (0.33-3.40) | 1.02 (0.32-3.28) |
| AT or TT and trauma | 52 | 26 | 2.12 (1.23-3.66) | 1.48 (0.83-2.65) |