Table 3.
Association between included gene polymorphisms and overall survival in osteosarcoma patients
| Genotypes | Death N = 66 | % | Alive N = 148 | % | Adjusted HR (95% CI)1 | P value |
|---|---|---|---|---|---|---|
| ERCC1 rs11615 | ||||||
| TT | 34 | 51.52 | 61 | 41.22 | 1.0 (Ref.) | - |
| TC | 24 | 36.36 | 58 | 39.19 | 0.74 (0.37-1.47) | 0.36 |
| CC | 8 | 12.12 | 29 | 19.59 | 0.43 (0.15-0.93) | 0.03 |
| ERCC2 rs1799793 | ||||||
| GG | 43 | 65.15 | 85 | 57.43 | 1.0 (Ref.) | - |
| GA | 19 | 28.79 | 45 | 30.41 | 0.83 (0.41-1.67) | 0.59 |
| AA | 4 | 6.06 | 18 | 12.16 | 0.44 (0.10-1.46) | 0.15 |
| ERCC2 rs13181 | ||||||
| AA | 39 | 59.09 | 82 | 55.41 | 1.0 (Ref.) | - |
| AC | 20 | 30.30 | 48 | 32.43 | 0.88 (0.43-1.75) | 0.69 |
| CC | 7 | 10.61 | 18 | 12.16 | 0.82 (0.27-2.27) | 0.68 |
| NBN rs709816 | ||||||
| GG | 27 | 40.91 | 57 | 38.51 | 1.0 (Ref.) | - |
| GC | 25 | 37.88 | 59 | 39.86 | 0.89 (0.44-1.81) | 0.74 |
| CC | 13 | 19.70 | 32 | 21.62 | 0.86 (0.35-2.01) | 0.7 |
| RAD51 rs1801320 | ||||||
| GG | 34 | 51.52 | 70 | 47.30 | 1.0 (Ref.) | - |
| GC | 25 | 37.88 | 59 | 39.86 | 0.87 (0.45-1.70) | 0.67 |
| CC | 7 | 10.61 | 19 | 12.84 | 0.76 (0.25-2.12) | 0.57 |
| XRCC3 rs861539 | ||||||
| CC | 34 | 51.52 | 69 | 46.62 | 1.0 (Ref.) | - |
| CT | 26 | 39.39 | 61 | 41.22 | 0.86 (0.44-1.67) | 0.64 |
| TT | 6 | 9.09 | 18 | 12.16 | 0.68 (0.20-2.00) | 0.45 |
1
Ajusted for age, tumor size, clinical stage, lymph mode metastasis and ER and PR status.