Table 1.
Effect of adiponectin on cellular cholesterol content at different concentrations in RAW 264.7 macrophages
| Adiponectin | Control | 1 µg/mL | 5 µg/mL | 10 µg/mL |
|---|---|---|---|---|
| TC (mg/dL) | 430 ± 42 | 406 ± 42* | 286 ± 26* | 200 ± 24* |
| FC (mg/dL) | 169 ± 18 | 160 ± 16* | 117 ± 15* | 84 ± 16* |
| CE (mg/dL) | 261 ± 24 | 246 ± 26* | 169 ± 16* | 116 ± 18* |
| CE/TC (%) | 60.6 | 60.5 | 59.1 | 58 |
The RAW 264.7 macrophages were incubated with 25 µg/mL apoA-I and with 1 µg/mL, 5 µg/mL and 10 µg/mL adiponectin for 24 h respectively. HPLC was performed to determine the cellular total cholesterol and free cholesterol. Data are the mean ± SD of three independent experiments.
*
P < 0.05 compared with the control group.