Table 5.
Prognostic parameters to predict stage progression in 118 cases of high grade non-muscle invasive urothelial carcinomas
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Variables | P value | HR | 95% CI | P value | HR | 95% CI |
| Sex | 0.840 | 1.163 | 0.267-5.061 | |||
| Multiplicity | 0.141 | 2.308 | 0.759-7.019 | |||
| Tumor size (cm) | 0.795 | 1.218 | 0.275-5.400 | |||
| pT stage | 0.902 | 1.081 | 0.312-3.739 | |||
| CIS | 0.868 | 0.920 | 0.345-2.453 | |||
| Invasive component (> 50%) | 0.004 | 3.908 | 1.544-9.888 | 0.004 | 4.306 | 1.577-11.758 |
| E2F1 | 0.009 | 4.050 | 1.424-11.521 | 0.038 | 3.204 | 1.066-9.623 |
| p27 (nucleus) | 0.028 | 3.230 | 1.137-9.172 | 0.120 | 2.401 | 0.796-7.241 |
Abbreviations: HR, hazard ratio; CI, confidence interval; LVI, lymphovascular invasion; CIS, carcinoma in situ.