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. 2014 Nov 3;124(12):5437–5441. doi: 10.1172/JCI76669

Figure 3. Reversal of impairment after a sedative dose of etomidate and the effects of an anesthetizing dose of etomidate.

Figure 3

(A–C) Effects of etomidate (8 mg/kg i.p.) on (A) memory performance in WT mice treated with L-655,708 (L6, 0.5 mg/kg, n = 6–11, 1-way ANOVA, Dunnett’s post-test), (B) memory performance in Gabra5–/– mice (n = 8–13, 1-way ANOVA, Dunnett’s post-test at each time point), and (C) plasticity at Schaffer collateral-CA1 synapses 24 hours after etomidate in Gabra5–/– slices. For all fPSP data, insets: traces recorded before (a) and 60 minutes after (b) 20-Hz stimulation. Bar graph shows summarized data for the last 5 minutes of recording (n = 7–8). (D–G) Effects of an anesthetizing dose of etomidate (20 mg/kg i.p.) in WT mice on (D) memory performance (n = 9–10), (E) plasticity (n = 6–7), (F) tonic current (n = 7–8), and (G) surface and total expression of α5 subunits (n = 4) in hippocampal slices 24 hours after etomidate. MW is shown as kDa. Data are shown as mean ± SEM. Unpaired, 2-tailed Student’s t test unless otherwise indicated. *P < 0.05; **P < 0.01.