Table 2. GO terms enriched in slow-evolving genes.

Gene ontology terms enriched in the set of 4,575 pairwise Culex pipiens forms pipiens and molestus homologous codon alignments devoid of non-synonymous substitutions.

GO ID	Go term	FDR	p	# in test set	# in ref. set	# unannot. test set	# unannot. reference set
GO:0003735	Structural constituent of ribosome	1.00E−15	7.60E−19	98	30	3209	5298
GO:0005525	GTP binding	2.70E−09	1.70E−11	113	67	3194	5261
GO:0007264	Small GTPase mediated signal transduction	2.90E−04	6.40E−06	104	89	3203	5239
GO:0051301	Cell division	2.50E−03	8.60E−05	27	12	3280	5316
GO:0007186	G-protein coupled receptor signaling pathway	4.10E−03	1.50E−04	76	66	3231	5262
GO:0003924	GTPase activity	6.60E−03	2.50E−04	54	42	3253	5286
GO:0030288	Outer membrane-bounded periplasmic space*	1.10E−02	4.60E−04	8	0	3299	5328
GO:0030054	Cell junction	1.30E−02	5.70E−04	28	16	3279	5312
GO:0004930	G-protein coupled receptor activity	1.80E−02	8.10E−04	45	35	3262	5293
GO:0000165	MAPK cascade*	2.50E−02	1.20E−03	7	0	3300	5328
GO:0006334	Nucleosome assembly	2.70E−02	1.40E−03	18	8	3289	5320
GO:0005509	Calcium ion binding	3.10E−02	1.60E−03	103	110	3204	5218
GO:0015991	ATP hydrolysis coupled proton transport	3.50E−02	1.90E−03	14	5	3293	5323
GO:0019843	rRNA binding	3.50E−02	1.90E−03	10	2	3297	5326
GO:0015986	ATP synthesis coupled proton transport	3.50E−02	1.90E−03	10	2	3297	5326
GO:0034765	Regulation of ion transmembrane transport	3.80E−02	2.10E−03	15	6	3292	5322
GO:0045211	Postsynaptic membrane	4.50E−02	2.70E−03	19	10	3288	5318
GO:0033180	Proton-transporting V-type ATPase, V1 domain*	5.00E−02	3.10E−03	6	0	3301	5328
GO:0000976	Transcription regulatory region sequence-specific DNA binding*	5.00E−02	3.10E−03	6	0	3301	5328

Notes.

^*indicate terms for which all members were present only in the test set.