Figure 2.

Summary of estrogen effects on AngII-sensitive neural circuits. The illustration summarizes the findings reviewed here regarding the specific hypothalamic connections that are affected by both estrogens and AngII. The different colors represent the primary ER subtype expressed in a given structure (ERα, blue; both ERβ and GPR30, red; both ERα and ERβ, purple). Structures in which AngII can act directly to stimulate water intake are highlighted by a yellow border around the label. The lack of a connection or a site of action depicted should not be viewed as evidence for the absence of any projection or effect, but simply reflects the lack of experimental support for its existence.