Table 1. HIF-1- and non-HIF-1-dependent reporters have differential responses to various stress treatments.
Stress | Treatment | GFP reporter induction? | |
---|---|---|---|
F45D3.4-3kb | NHR-57 | ||
Anoxia | 0.0% O2 | No | No |
Hypoxia | 0.1–0.4% O2 | Yes | Yes |
Hypoxia | 0.5% O2 | No | Yes |
CoCl2 | 1.42–4.76 mM | Yes | No |
Osmotic | 300 mM NaCl | No | No |
Heat | 37° 6 hr | No | No |
ROS | 4 mM paraquat | No | Yes |
Starvation | 12 hr | Yes | No |
Heavy metal | 0.02 mM NiCl2 | No | No |
Calcium chelation | 0.4.76 mM EGTA | No | No |