Table 1. Genes that affect touch sensitivity.
| Gene Name | Description | Confirmed by Mutation |
|---|---|---|
| Transcription and translation related | ||
| Y47H9C.7 | EIF2B β subnit homolog | |
| TAF-5 | TAF (TBP-associated transcription factor) family | |
| taf-9 | TAF (TBP-associated transcription factor) family | |
| nars-1 | Asparaginyl-tRNA synthetase | |
| mog-5 | DEAH RNA helicase orthologous to PRP22 proteins. | Yes |
| hars-1 | Aistidyl-tRNA synthetase (HisRS) | |
| F54D5.11 | TFIIE β subunit | |
| xrn-2 | 5′->3′ exonuclease | |
| C48E7.2 | RNAPol IIIC homolog | |
| D2085.3 | EIF2B ε subunit | |
| F55F8.3 | WD40-repeat-containing subunit of the 18S rRNA processing complex | |
| F19F10.9 | Human SART1 homolog, U4/U6.U5 tri-snRNP−associated protein 1 | |
| Transcription and splicing control | ||
| dmd-5 | Doublesex/mab-3 like | |
| mfap-1 | Microfibrillar-associated protein homolog, controls alternative splicing | |
| Protein degradation | ||
| pas-4 | Proteasome α-type seven subunit of the core 20S proteasome subcomplex | |
| rpn-1 | Non-ATPase subunit of proteasome 19S regulatory subcomplex | |
| Calcium signaling | ||
| mca-3 | Plasma membrane Ca2+ ATPase | Yes |
| cal-2 | Calmodulin homolog | |
| unc-43 | CaMKII | Yes |
| Adhesion/focal adhesion complex | ||
| pxl-1 | Paxillin 1 | |
| pat-2a | α-integrin subunit | Yes |
| pat-4a | Integrin-linked kinase | Yes |
| pat-6a | α-parvin (Actopaxin) | Yes |
| unc-112a | Orthologous to human mitogen-inducible gene-2 | Yes |
| unc-97a | LIM domain-containing protein of the PINCH family | Yes |
| lam-2 | Laminin γ subunit | |
| hmr-1 | Classical cadherin | |
| Cytoskeleton and cell division | ||
| ifa-3 | Essential intermediate filament protein | |
| pfd-3 | Putative prefoldin, orthologous to human VBP1 that is required for α-tubulin synthesis | |
| tag-170/txdc-9 | Thioredoxin domain-containing protein orthologous to human TXNDC9 | Yes |
| cdk-1 | Cyclin-dependent kinase, orthologous to CDC28 from S. cerevisiae | Yes |
| fzy-1 | An ortholog of S. cerevisiae Cdc20, predicted to regulate metaphase-anaphase transition | Yes |
| knl-1 | Novel acidic protein, kinetochore component | |
| myo-3 | Myosin heavy chain A | |
| Endo/exocytosis and synaptic functions | ||
| tom-1 | Tomosyn ortholog, binds SNAP25 (RIC-4) | Yes |
| unc-11 | Clathrin-adaptor protein AP180 | Yes |
| cab-1 | Novel protein with a C-terminal motif weakly homologous to NPDC-1 | Yes |
| Mitochondria | ||
| T20H4.5 | 23-kDa subunit of mitochondrial complex I | |
| Y37D8A.18 | Mitochondrial ribosomal protein, small | |
| F43E2.7 | Mitochondrial carrier nomolog | |
| Signaling pathways | ||
| ptc-1 | Ortholog of Drosophila PATCHED (PTC) and human PTCH | Yes |
| ptc-3 | Ortholog of Drosophila PATCHED (PTC) and human PTCH | |
| goa-1 | Heterotrimeric G protein α subunit Go (Go/Gi class) | Yes |
| kin-18 | TAO kinase | Yes |
| let-502 | Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM kinase) | Yes |
| let-92 | Catalytic subunit of protein phosphatase 2A (PP2A) | Yes |
| F47F2.1 | PKA homolog | |
| R03E1.2 | Renin receptor homolog | |
| Others | ||
| nsf-1 | NSF (N-ethylmaleimide sensitive secretion factor) homolog, may be required for ER to Golgi transport | |
| gfi-2 | GEI-4 (four) interacting protein | |
| glf-1 | UDP-galactopyranose mutase | |
| K12H4.4 | Signal peptidase complex subunit | |
| pnk-1 | Pantothenate kinase | Yes |
| saps-1 | SAPS (phosphatase-associated) domain protein | |
| vha-5 | Subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase) | Yes |
| crn-1 | Cell death−related 5′-3′ exonuclease, homologous to mammalian flap endonuclease 1 (FEN1) | |
| cgt-3 | Ceramide glucosyltransferase, required for glycosphingolipid production | Yes |
| sqv-3 | β-(1,4)-galactosyltransferase, required for cytokinesis | Yes |
| T19B10.2 | Nematode-specific protein | |
| F26G1.2 | Nematode-specific protein | |
| C30B5.6 | Unknown protein |
Gene names and their inferred homologies are listed. The genes were grouped according to their putative functions and/or the functions of their orthologs. tRNA, transfer RNA; ER, endoplasmic reticulum; SAPS, SIT4 phosphatase–associated protein.
a
Five positive controls previously shown to affect touch sensitivity (Chen and Chalfie 2014).