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VSM function was impaired following CeO2 NP exposure and was not exposure route-dependent. Soluble GC activation was assessed with YC-1 (A, n = 8–11). Cyclic GMP responsiveness was assessed with 8-bromo-cGMP (B, n = 10). *p ≤ 0.05 versus control, †p ≤ 0.05 versus intratracheal instillation. The brackets indicate differences in the overall slope of the determination.
