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. 2014 Dec 5;144(1):77–89. doi: 10.1093/toxsci/kfu256

FIG. 7.

FIG. 7.

Vasodilation in response to ACh following incubation with either L-NMMA (10−4 M), INDO (10−5 M), or both inhibitors. There was a significant impairment in dilation of control arterioles following incubation with L-NMMA and INDO (A, n = 14–34). There was a partial restoration in function following incubation with L-NMMA after intratracheal instillation of 65 µg CeO2 NP (B, n = 5–14). Intravenous injection of 100 µg CeO2 NP caused an attenuated response to ACh after incubation with INDO that was significantly different from the CeO2 NP exposure alone (C, n = 5–9). Gastric gavage of 400 µg CeO2 NP caused a significant impairment in arteriolar dilation following L-NMMA incubation compared with the CeO2 NP exposure alone (D, n = 8–15). *p ≤ 0.05 versus L-NMMA (10−4 M), †p ≤ 0.05 versus INDO (10−5 M), ‡p ≤ 0.05 versus both inhibitors, ^p ≤ 0.05 versus CeO2 NP exposure. The brackets indicate differences in the overall slope of the determination.