TABLE 1.
Animal Characteristics
| Groups | N | Age (weeks) | Weight (g) | MAP (mm Hg) | Heart Weight (g) |
|---|---|---|---|---|---|
| Control-Saline | 41 | 10.61 ± 0.4 | 392 ± 10 | 105 ± 4 | 1.28 ± 0.03 |
| Intravenous injection dose-response determination | |||||
| 50 µg CeO2 NP | 7 | 8.43 ± 0.3 | 338 ± 8 | 102 ± 2 | 1.22 ± 0.02 |
| 100 µg CeO2 NP | 8 | 9.76 ± 0.09 | 382 ± 3 | 112 ± 3 | 1.34 ± 0.01 |
| 900 µg CeO2 NP | 8 | 9.50 ± 0.28 | 364 ± 6 | 107 ± 2 | 1.31 ± 0.02 |
| Gastric Gavage Dose-Response Determination | |||||
| 100 µg CeO2 NP | 9 | 10.11 ± 0.4 | 383 ± 11 | 98 ± 4 | 1.30 ± 0.03 |
| 300 µg CeO2 NP | 8 | 9.38 ± 0.6 | 371 ± 17 | 100 ± 3 | 1.33 ± 0.04 |
| 600 µg CeO2 NP | 8 | 8.88 ± 0.4 | 376 ± 18 | 96 ± 4 | 1.29 ± 0.06 |
| Calculated EC50 doses (µg) | |||||
| 65 µg CeO2 NP (0.19 mg/kg via intratracheal instillation) | 14 | 9.45 ± 0.1 | 381 ± 4 | 99 ± 2 | 1.29 ± 0.02 |
| 100 µg CeO2 NP (0.29 mg/kg via intravenous injection) | 11 | 9.27 ± 0.1 | 384 ± 5 | 109 ± 1 | 1.32 ± 0.03 |
| 400 µg CeO2 NP (1.14 mg/kg via gastric gavage) | 21 | 9.59 ± 0.2 | 365 ± 8 | 98 ± 5 | 1.36 ± 0.07 |
Notes: Values are means ± SE. N = number of animals. MAP = mean arterial pressure. The mg/kg concentrations were calculated based on a representative animal weight of 350 g.