TABLE 4.

miRNAs Associated with Fibrosis Based on IPA Analysis and Their Experimentally Confirmed and Predicted mRNA Binding Partners

miRBase ID	Accession	Experimentally Confirmed Targets (miRTarBase/miRecords)	Predicted Targets (TargetScan, Highly Conserved)	IPA Relationships (TargetScan, Poorly Conserved)
mmu-miR-125-5p	MIMAT0000136	il1rn (Hofmann et al., 2009), tnf (Tili et al., 2007), tnfaip3 (Kim et al., 2012), mmp13 (Xu et al., 2012)	bmpr2, smad4, tnfrsf1b, vegfa	bmpr2, tnfrsf1b, smad4
mmu-miR-126a-3p	MIMAT0000138	vegfa (Zhu et al., 2011)
mmu-miR-141-3p	MIMAT0000153		csf3	hmgcs1, tnfaip3, egfr
mmu-miR-16-5p	MIMAT0000527	vegfa (Karaa et al., 2009), kncc4 (Selbach et al., 2008), egfr (Selbach et al., 2008), vim (Selbach et al., 2008), smurf2 (Bockhorn et al., 2013)	cxcl1	ptgs2 (Selbach et al., 2008), ago1, igf1
mmu-miR-18a-3p	MIMAT0004626	hif1a (Hafner et al., 2010), smad4 (Dews et al., 2010), hmgcs1 (Hafner et al., 2010)	igf1, tnfaip3
mmu-miR-199a-5p	MIMAT0000229	hif1a (Rane et al., 2009), smad4 (Zhang et al., 2012b)	gsk3b, serpine1, vegfa	vegfa, ago1, ednrb, gsk3b, serpine1
mmu-miR-21a-5p	MIMAT0000530	fas (Sayed et al., 2010), bmpr2 (Papagiannakopoulos et al., 2008), egfr (Zhou et al., 2010), plat (Terao et al., 2011), ptx3 (Terao et al., 2011), tnfaip3 (Terao et al., 2011), ccr1 (Terao et al., 2011), vegfa (Liu et al., 2011), mmp9 (Moriyama et al., 2009), ptk2 (Gabriely et al., 2008), arid4a (Gabriely et al., 2008)		smurf2, tnf (Zhang et al., 2012a)
mmu-miR-26a-5p	MIMAT0000533	egr1 (Chi et al., 2009), smad4 (Dey et al., 2012), gsk3b (Mohamed et al., 2010), il6 (Yang et al., 2013), ago1 (Helwak et al., 2013)	mmp14, ptgs2, ptx3	igf1
mmu-miR-30c-5p	MIMAT0000514	socs1 (Zhang et al., 2013), vim (Bockhorn et al., 2013), ago1 (Helwak et al., 2013)	actc1, arid4a, ednrb, igf1	igf1, actc1, arid4a, serpine1
mmu-miR-322-5p	MIMAT0000548		cx3cl1, kcnn4, ptgs2, smurf2, vegfa

Note: Significantly changed miRNAs are highlighted in bold.