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. 2015 Jan 26;144(1):151–162. doi: 10.1093/toxsci/kfu265

FIG. 10.

FIG. 10.

At Day 21 post IT of Ag NPs, foamy and irregular macrophages dominate the alveolar airspaces. Panels are brightfield microscopy images contrasting the most severe responses in H&E-stained tissue sections, from rats instilled with a single dose of 1.0 ml/kg citrate buffer (sham control [A]), C20 (B), C110 (C), 40 kDa PVP buffer (sham control [D]), P20 (E), or P110 (F). Response to 10 kDa PVP buffer is not shown but similar to that in Panel D. Broken arrows indicate remaining PMNs. Solid arrows show cellular exudate resulting from Ag NP exposure. Scale bar is 25 µm.