Table 2. Genotypic frequency of CD209 polymorphisms between sickle cell and control groups.
Genotypic frequencies of the CD209 gene promoter (rs4803803) polymorphism, determined among African and American sickle cell disease and control groups. Sickle cell disease (HbSS) populations were recruited from Bamako, Mali (African) and Augusta GA (American). Control populations are individuals without sickle cell disease, and were recruited from Mali (African) and Shreveport LA (American). A/G denotes the alleles at the CD209 locus. Odds ratio was calculated by Fisher’s two-tailed exact test. P value <0.05 was considered significant.
| African | |||||
|---|---|---|---|---|---|
| Polymorphism | Genotype | SCD: n = 145 (%) |
Controls: n = 231 (%) |
Odds ratio (95% CI) |
P-value |
| CD209 (rs4804803) | A/A | 45 (31.0) | 60 (26.0) | 1.28 (0.79-2.08) | 0.29 |
| A/G | 85 (58.6) | 117 (50.6) | 1.38 (0.89-2.15) | 0.14 | |
| G/G | 15 (10.4) | 54 (23.4) | 0.38 (0.19-0.72) | 0.002 | |
| African American | |||||
|
SCD: n = 331 (%) |
Controls: n = 379 (%) |
Odds ratio
(95% CI) |
P-value | ||
| CD209 (rs4804803) | A/A | 110 (33.2) | 124 (32.7) | 1.02 (0.74–1.42) | 0.94 |
| A/G | 171 (51.7) | 191 (50.4) | 1.05 (0.77–1.43) | 0.76 | |
| G/G | 50 (15.1) | 64 (16.9) | 0.88 (0.57–1.33) | 0.54 | |