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. 2015 Mar 4;6:84. doi: 10.3389/fgene.2015.00084

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Copyright © 2015 Fenger, Linneberg and Jeppesen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between relative epistasis and WMI. The plots shows the heritability (Geno/Pheno) of the diastolic blood pressure as a function of the weighted mutual information (the plots of systolic blood pressure are similar). Subpopulation 8 was evaluated at an allocation threshold of 0.7 in contrast to 0.9 for all the other subpopulation (see Text for discussion). The three fitted plots [polynomial, Boltzmann (sigmoid), and Gaussian] were almost overlapping. Apart from the ubiquitous ASAH1 and SPHK1 haplotypes there is a difference in the ranking of the next interactions between the subpopulations. Similar differences in patterns were seen for the other subopulations.