Table 3.
Prevalence of affected for two-SNP genotypes.
| Fraction (%)* | ||||||||
|---|---|---|---|---|---|---|---|---|
| SNP1 | Gene1 | Genotype1 | SNP2 | Gene2 | Genotype2 | p-value | Genotype | Population |
| DIASTOLIC BLOOD PRESSURE | ||||||||
| Genotypes above the threshold | ||||||||
| rs865832 | SGPL1 | TT | rs12770335 | SGPL1 | GG | 0.0138 | 50 | 1.62 |
| rs309087 | LPPR5 | CC | rs5186 | AGTR1 | CC | 0.0279 | 50 | 1.3 |
| rs3734462 | AGPAT4 | TT | rs1799983 | NOS3 | TT | 0.0279 | 50 | 1.3 |
| rs1799883 | FABP2 | AA | rs1799983 | NOS3 | TT | 0.0220 | 45.45 | 1.62 |
| rs28385609 | SMPDL3A | TT | rs2003149 | KDSR | GA | 0.0182 | 36.36 | 2.6 |
| rs309087 | LPPR5 | CC | rs5186 | AGTR1 | CA | 0.0401 | 34.78 | 2.6 |
| rs243887 | SPTLC3 | TT | rs1071645 | ASAH1 | AG | 0.0123 | 26.97 | 7.79 |
| rs243887 | SPTLC3 | TT | rs1049874 | ASAH1 | GA | 0.0130 | 26.67 | 7.79 |
| rs41292584 | SMPDL3A | CT | rs1799983 | NOS3 | GG | 0.0308 | 25 | 7.47 |
| rs41292584 | SMPDL3A | CT | rs3739709 | LPAR1 | CC | 0.0313 | 23.53 | 10.39 |
| rs1138439 | PPAP2C | TT | rs12195587 | ELOVL2 | TC | 0.0451 | 23.39 | 9.42 |
| rs1138439 | PPAP2C | TT | rs2003149 | KDSR | GA | 0.0377 | 23.13 | 11.04 |
| rs3811514 | SPHKAP | GG | rs3828161 | SPHKAP | AA | 0.0371 | 22.17 | 14.61 |
| Genotypes below the threshold | ||||||||
| rs1799983 | NOS3 | GT | rs2566514 | NOS3 | CC | 0.0008 | 10.18 | 16.23 |
| rs3739968 | ASAH2B | GG | rs1071645 | ASAH1 | GG | 0.0341 | 10.16 | 6.17 |
| rs285 | LPL | TT | rs320 | LPL | GT | 0.0224 | 10.14 | 7.14 |
| rs3739968 | ASAH2B | GG | rs1049874 | ASAH1 | AA | 0.0314 | 9.94 | 5.84 |
| rs1799983 | NOS3 | GT | rs3828161 | SPHKAP | GA | 0.0123 | 9.87 | 7.47 |
| rs1130233 | AKT1 | AG | rs3828161 | SPHKAP | GA | 0.0215 | 9.84 | 6.17 |
| rs6109692 | SPTLC3 | CT | rs2241883 | FABP1 | GA | 0.0430 | 9.79 | 4.55 |
| rs11657217 | ENPP7 | GG | rs3734462 | AGPAT4 | TC | 0.0479 | 6.67 | 1.3 |
| rs6511701 | S1PR5 | GT | rs1695 | GSTP1 | GG | 0.0358 | 6.15 | 1.3 |
| rs11657217 | ENPP7 | GG | rs3170633 | GCLM | GG | 0.0010 | 4.35 | 1.3 |
| rs4880 | SOD2 | TT | rs11657217 | ENPP7 | GG | 0.0253 | 4.17 | 0.65 |
| rs5186 | AGTR1 | CC | rs67319648 | PPAPDC1A | CT | 0.0485 | 3.23 | 0.32 |
| SYSTOLIC BLOOD PRESSURE | ||||||||
| Genotypes above the threshold | ||||||||
| rs398607 | GALC | CC | rs36211083 | CERK | TT | 0.0130 | 100 | 0.67 |
| rs398607 | GALC | TT | rs1805078 | GALC | TC | 0.0124 | 80 | 0.89 |
| rs1130233 | AKT1 | AA | rs3828161 | SPHKAP | GG | 0.0302 | 66.67 | 0.89 |
| rs243887 | SPTLC3 | TT | rs2241883 | FABP1 | GG | 0.0206 | 50 | 2.01 |
| rs1799983 | NOS3 | GT | rs3828161 | SPHKAP | GG | 0.0236 | 42.86 | 2.68 |
| rs1130435 | FABP6 | CC | rs7157599 | DEGS2 | GG | 0.0296 | 38.64 | 3.8 |
| rs7850023 | MIR4668 | AG | rs5186 | AGTR1 | CC | 0.0400 | 36.73 | 4.03 |
| rs5186 | AGTR1 | AA | rs2301022 | GCLM | AA | 0.0169 | 33.63 | 8.5 |
| rs1476387 | SMPD2 | TT | rs3739709 | LPAR1 | CT | 0.0312 | 33.33 | 7.61 |
| rs3739968 | ASAH2B | GA | rs4918 | AHSG | GG | 0.0178 | 33.07 | 9.4 |
| rs285 | LPL | CC | rs1695 | GSTP1 | AA | 0.0136 | 31.43 | 14.77 |
| rs12195587 | ELOVL2 | TC | rs1476387 | SMPD2 | GG | 0.0183 | 30.84 | 14.77 |
| rs1138439 | PPAP2C | TT | rs7302981 | CERS5 | CC | 0.0408 | 30.77 | 10.74 |
| rs6511701 | S1PR5 | GT | rs1695 | GSTP1 | AA | 0.0123 | 30.63 | 18.57 |
| rs285 | LPL | CC | rs7157599 | DEGS2 | AA | 0.0321 | 29.8 | 16.33 |
| rs12195587 | ELOVL2 | TC | rs8176328 | SPHK1 | AG | 0.0182 | 29.77 | 20.58 |
| rs12195587 | ELOVL2 | TC | rs2247856 | SPHK1 | TC | 0.0195 | 29.65 | 21.03 |
| rs12195587 | ELOVL2 | TC | rs698912 | COL4A3BP | AA | 0.0407 | 28.42 | 23.71 |
| Genotypes below the threshold | ||||||||
| rs6511701 | S1PR5 | GG | rs1868158 | SMPD3 | AG | 0.0492 | 19.35 | 23.94 |
| rs12195587 | ELOVL2 | CC | rs2247856 | SPHK1 | TC | 0.0338 | 19.21 | 26.17 |
| rs11657217 | ENPP7 | CC | rs402348 | KDSR | CA | 0.0359 | 17.34 | 9.62 |
| rs285 | LPL | TT | rs328 | LPL | CC | 0.0183 | 17.32 | 11.86 |
| rs1799983 | NOS3 | GG | rs3828161 | SPHKAP | GA | 0.0119 | 16.33 | 8.95 |
| rs3811515 | SPHKAP | GT | rs16824283 | SPHKAP | CG | 0.0137 | 16.32 | 8.72 |
| rs1138439 | PPAP2C | CC | rs36211083 | CERK | TC | 0.0488 | 15.18 | 3.8 |
| rs398607 | GALC | TT | rs36211083 | CERK | TC | 0.0191 | 13.13 | 2.91 |
| rs1049874 | ASAH1 | AA | rs4808863 | CERS1 | TT | 0.0237 | 12.16 | 2.01 |
| rs1071645 | ASAH1 | GG | rs4808863 | CERS1 | TT | 0.0237 | 12.16 | 2.01 |
| rs243887 | SPTLC3 | TT | rs1049874 | ASAH1 | AA | 0.0268 | 9.8 | 1.12 |
| rs243887 | SPTLC3 | TT | rs1071645 | ASAH1 | GG | 0.0192 | 9.43 | 1.12 |
| rs320 | LPL | GG | rs328 | LPL | CC | 0.0282 | 9.09 | 0.89 |
| COMMON TO BOTH DIASTOLIC AND SYSTOLIC BLOOD PRESSURE | ||||||||
| Genotypes above the respective thresholds | Diastolic/systolic blood pressure | |||||||
| rs79875317 | SMPD4 | AA | rs1695 | GSTP1 | GG | 0.002/0.001 | 71.43/54.17 | 1.62/2.91 |
| rs76033185 | SMPD4 | GG | rs1695 | GSTP1 | GG | 0.008/0.003 | 66.67/83.33 | 1.30/1.12 |
| rs1138439 | PPAP2C | TT | rs36211083 | CERK | TT | 0.044/0.038 | 44.44/55.56 | 1.30/1.12 |
| rs2297568 | SPTLC1 | AG | rs3828161 | SPHKAP | GG | 0.010/0.001 | 37.50/54.17 | 2.92/2.91 |
| rs12888666 | GALC | AA | rs1695 | GSTP1 | AA | 0.049/0.013 | 25.00/35.71 | 6.82/6.71 |
| rs1130233 | AKT1 | AA | rs243887 | SPTLC3 | TT | 0.014/0.015 | 50.00/60.00 | 1.62/134 |
| rs11657217 | ENPP7 | CG | rs402348 | KDSR | CA | 0.016/0.043 | 22.27/29.3 | 18.51/16.78 |
| Genotypes below the respective thresholds | ||||||||
| rs3734462 | AGPAT4 | TC | rs1049874 | ASAH1 | AA | 0.020/0.043 | 9.73/16.76 | 5.84/6.94 |
| rs11657217 | ENPP7 | GG | rs402348 | KDSR | CA | 0.013/0.043 | 4.76/29.30 | 0.97/16.78 |
Prevalence of diastolic hypertension in the population 16.13% (threshold).
Number of subjects with diastolic hypertension captured by the significant genotypes 253 (82.14% of all affected).
Prevalence of systolic hypertension in the population 23.40% (threshold).
Number of subjects with systolic hypertension captured by the significant genotypes 436 (97.54% of all affected).
Genotypes in bold, missense mutations; genotypes in italic, synonymous mutations.
For gene abreviations, please see Supplemental Data Table S1a.
*
Freqencies of the affected by the two-SNP genotype (Genotype) and frequencies of the two-SNP genotype in the population (Population).