Table 1.

(A) Map-related granulomatous diseases. (B) Map-associated autoimmune diseases.

(A) MAP-RELATED GRANULOMATOUS DISEASES
Disease	Shared genetic susceptibility	Reference
Crohn’s	CARD15, SLC11A1	(8, 51, 52, 57, 59, 62, 64)
Sarcoidosis	SLC11A1	(54, 69)
Blau syndrome	CARD15	(52–56, 60)
These granulomatous diseases are ones where evidence of MAP can be found in the granuloma. CARD15, caspase recruitment domain gene 15; SLC11a1, solute carrier 11a1 gene.
(B) MAP-ASSOCIATED AUTOIMMUNE DISEASES
Disease	Mimicking elements	Reference
Autoimmune diabetes	HSP65/GAD	(31, 86–88, 90–94)
	MAP3865c/ZnT8 – pancreatic
Autoimmune thyroiditis	MAP3865c/ZnT8 – thyroid	(35, 36)
Multiple sclerosis	HSP70, MAP_2694, MAP4027, MAP_2619c 352-61, MAP_0106c protein 121–132	(37–49)

These autoimmune diseases have autoantibodies. There are share molecular elements between MAP proteins and host organs. HSP65, heat shock protein 65; GAD, glutamic acid decarboxylase; MAP3865c, M. paratuberculosis protein 3865c; ZnT8, zinc transporter 8; HSP70, heat shock protein 70; MAP-0106c, M. paratuberculosis 0106c protein (aa. 121–132); MBP85-98, myelin basic protein (aa. 85–98).