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. Author manuscript; available in PMC: 2015 Mar 4.
Published in final edited form as: Cancer. 2011 Feb 24;117(17):3999–4008. doi: 10.1002/cncr.25983

Figure 2.

Figure 2

Lenalidomide modulates the absolute numbers of TCR-activated CD4+ T cells that synthesized (a) IL-2, (b) IFN-γ, (c) TNF-α, and (d) IL-10. Data obtained from healthy subjects are shown on the right side of each figure. Asterisks represent significant differences between responses of healthy subjects (HS) and those of CLL patients at the designated time points during treatment. Solid line represents significant differences in activated CD4+ T cells synthesizing cytokines between pretreatment versus after 3 cycles of therapy; dashed line represents significant differences between after 3 cycles versus after 15 cycles of therapy.