Table IV.
Adverse events (AEs) occurring in ≥ 15% of patients treated with obatoclax + bortezomib (n = 23).
| AE, n (%) | All grades | Grade 3 | Grade 4 |
|---|---|---|---|
| Hematologic events | |||
| Thrombocytopenia | 10 (44) | 1 (4) | 4 (17)* |
| Anemia | 9 (39) | 2 (9) | 1 (4) |
| Neutropenia | 4 (17) | 0 | 1 (4) |
| Non-hematologic events | |||
| Somnolence | 20 (87) | 1 (4) | 0 |
| Fatigue | 14 (61) | 3 (13) | 0 |
| Euphoric mood | 13 (57) | 0 | 0 |
| Diarrhea | 11 (48) | 1 (4) | 0 |
| Nausea | 11 (48) | 2 (9) | 0 |
| Vomiting | 10 (44) | 0 | 0 |
| Peripheral neuropathy | 10 (44) | 0 | 1 (4) |
| Dizziness | 8 (35) | 1 (4) | 0 |
| Rash | 8 (35) | 0 | 0 |
| Cough | 7 (30) | 0 | 0 |
| Abdominal pain | 6 (26) | 1 (4) | 0 |
| Constipation | 6 (26) | 0 | 0 |
| Peripheral edema | 6 (26) | 2 (9) | 0 |
| Hypomagnesemia | 6 (26) | 0 | 0 |
| Headache | 6 (26) | 0 | 0 |
| Ataxia | 5 (22) | 1 (4) | 0 |
| Confusion | 5 (22) | 2 (9) | 0 |
| Stomatitis | 4 (17) | 0 | 0 |
| Weight loss | 4 (17) | 1 (4) | 0 |
| Dehydration | 4 (17) | 1 (4) | 0 |
| Hyperglycemia | 4 (17) | 1 (4) | 0 |
| Pruritus | 4 (17) | 0 | 0 |
| Hypotension | 4 (17) | 1 (4) | 0 |
*
Two of these patients had thrombocytopenia at baseline (one grade 1 and one grade 3).