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. 2015 Jan 30;25(3):318–334. doi: 10.1038/cr.2015.12

Figure 4.

Figure 4

FXYD2 is required for maintaining inflammatory nociceptive responses. (A) The drop latency of Fxyd2−/− mice was similar to that of Fxyd2+/+ mice in rotarod test (n = 14 for Fxyd2+/+ and n = 10 for Fxyd2−/− mice). (B) The Hargreaves test showed that the thermal latency of Fxyd2−/− mice was not altered compared to Fxyd2+/+ mice (n = 10 for both Fxyd2+/+ and Fxyd2−/− mice). (C) The hotplate test showed that thermal latency at 50, 52, and 55 °C was unchanged between Fxyd2+/+ and Fxyd2−/− mice (n = 11 for Fxyd2+/+ and n = 12 for Fxyd2−/− mice). (D) The mechanical threshold of Fxyd2−/− mice was slightly increased compared to that of Fxyd2+/+ mice (n = 14 for Fxyd2+/+ and n = 16 for Fxyd2−/− mice). (E) The Fxyd2−/− mice did not show any apparent changes in the number of flinches in either the first or the second phase of the formalin test (n = 11 for both Fxyd2+/+ and Fxyd2−/− mice). (F) The radiant heat test showed that recovery from the thermal hyperalgesia was facilitated in Fxyd2−/− mice 2 days after CFA injection (n = 10 for both Fxyd2+/+ and Fxyd2−/− mice). (G) The von Frey test showed that the mechanical allodynia was maintained only in Fxyd2+/+ mice and not in Fxyd2−/− mice 2 days after CFA injection (n = 9 for both Fxyd2+/+ and Fxyd2−/− mice, ***P < 0.001).