Table 1. A comparison of clinical characteristics of patients with ACTH-secreting PAs with or without USP8 mutations.
| Characteristic | WT (n = 45) | Mutant (n = 75) | P value | |
|---|---|---|---|---|
| Age at diagnosis (Year) | ||||
| Median | 40 | 36 | 0.08† | |
| Interquartile range | 29.5-46.0 | 26.0-42.0 | ||
| Body Mass Index (BMI) | ||||
| Median | 25.4 | 24.2 | 0.36† | |
| Interquartile range | 21.6-27.8 | 22.4-26.7 | ||
| Plasma corticotropin (ACTH) (pg/ml) | ||||
| Median | 94.0 | 68.8 | 0.054† | |
| Interquartile range | 60.6-163.0 | 51.4-105.5 | ||
| ACTH (pg/ml)/Size (cm) | ||||
| Median | 51.0 | 103.0 | < 0.001† | |
| Interquartile range | 31.5-104.6 | 76.3-201.7 | ||
| Midnight serum cortisol (μg/dl) | ||||
| Median | 21.82 | 22.86 | 0.79† | |
| Interquartile range | 16.18-31.20 | 18.35-29.41 | ||
| Urinary free cortisol (μg/24 h) | ||||
| Median | 650.24 | 552.64 | 0.39† | |
| Interquartile range | 412.13-1168.25 | 262.75-977.47 | ||
| Immediate postoperative biochemical remission (%)Φ | ||||
| Yes | 33(73.3) | 63(84.0) | 0.16‡ | |
| No | 12(26.7) | 12(16.0) | ||
| Postoperative recurrence (%)я | ||||
| Yes | 8(25.8) | 12(20.7) | 0.58‡ | |
| No | 23(74.2) | 46(79.3) | ||
| Average recurrence period (month) | ||||
| Median | 48 | 29 | 0.28† | |
| Interquartile range | 15.0-48.0 | 16.3-38.3 | ||
†Values were compared by Mann-Whitney U-test.
‡Values were compared by Pearson's χ2 test.
ΦImmediate postoperative biochemical remission was defined on the basis of the biochemical evidence of adrenal cortical insufficiency as witnessed by the drop in the immediate postoperative serum cortisol (range, < 3 μg/dL).
яPostoperative recurrence was defined when a patient with initial biochemical and clinical evidence for remission after operation developed symptomatic recurrence of Cushing disease with biochemical reconfirmation of pituitary-dependent endogenous hypercortisolism.
Summary of patient number for each parameter:
Age: Data were available for 45 patients with no mutation and 75 patients with mutation.
BMI: Data were available for 45 patients with no mutation and 75 patients with mutation.
ACTH: Data were available for 43 patients with no mutation and 65 patients with mutation.
ACTH/Size: Data were available for 32 patients with no mutation and 51 patients with mutation.
Midnight serum cortisol: Data were available for 29 patients with no mutation and 45 patients with mutation.
Urinary free cortisol: Data were available for 28 patients with no mutation and 41 patients with mutation.
Immediate postoperative biochemical remission: Data were available for 45 patients with no mutation and 75 patients with mutation.
Postoperative recurrence: Among patients who reached immediate postoperative biochemical remission, long-term follow-up was performed in 33 cases with no mutation (2 were lost) and 63 cases with mutation (5 were lost).
Average recurrence period: In no mutation group, data were available for 8 recurrent patients, while in mutation group, data were available for 12 recurrent patients.