Table 1.

Demographic characteristics and serum antibody levels in children with FPIES (milk-FPIES: children with FPIES to milk, milk-FPIES-resolved: children with milk FPIES that resolve this intolerance, other-food-FPIES: children with FPIES to foods other than milk) and negative controls (children who never experienced any type of milk intolerance).

	Milk-FPIES (n=26)	Milk-FPIES-resolved (n=5)	Other-food FPIES (n=12)	p-value1	Negative controls (n=6)	p-value2
Age (years)	3.5 (2.3–5.7)	2 (2–3.1)	3.81 (2.7–6.8)	0.864*	3.6 (2–6)	0.741*
Gender (male)	14	3	9	0.432§	4	0.675§
Total IgE (kUA/L)	15.8 (3.7–36)	80.8 (22.5–98.7)	34 (10–133)	0.293*	45.7 (15.1–67)	0.451
Total IgA (mg/ml)	0.78 (0.4–1.136)	0.359 (0.26–0.45)	0.557 (0.42–1.01)	0.446*	0.4 (0.3–1.1)	0.570*
Casein specific IgG (mgA/L)	3.9 (2.8–5.8)	5.8 (1.9–7.2)	14.3 (8.9–36.5)	<0.001*	19.8 (7.5–35)	-
Casein specific IgG4 (μgA/L)	0.17 (0.08–0.26)	0.3 (0.1–1.9)	3.3 (0.3–11.5)	0.012*	5.02 (2.53–9.5)	-

values present in median (IQR), n: number of subjects

¹comparison among three first columns

²comparison among the negative controls and the three first columns

^*p-values based on Kruskal-Wallis rank test

^§p-value based on X² test